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Description
human bsep vesicle kit hek293Das Human BSEP Vesicle Kit enthlt Inside out Membranvesikel aus HEK293 Zellen, die transient die Bile Salt Export Pump (BSEP ABCB11) berexprimieren. BSEP ist der primre hepatische Efflux Transporter fr Gallensalze und ein zentrales Zielprotein in der Risikoabschtzung fr medikamenteninduzierte Cholestase (DILI). Das Kit ist konform mit den FDA (2017) und EMA (2013) Leitlinien fr DDI Studien. Hergestellt von Cell4Pharma. Exklusiv im DACH Raum erhltlich
Das Human BSEP Vesicle Kit enthält Inside-out Membranvesikel aus HEK293-Zellen, die transient die Bile Salt Export Pump (BSEP / ABCB11) überexprimieren. BSEP ist der primäre hepatische Efflux-Transporter für Gallensalze und ein zentrales Zielprotein in der Risikoabschätzung für medikamenteninduzierte Cholestase (DILI). Das Kit ist konform mit den FDA (2017)- und EMA (2013) Leitlinien für DDI Studien.
Hergestellt von Cell4Pharma. Exklusiv im DACH-Raum erhältlich über SeamlessBio.
Transporter-Profil
Name: BSEP, Bile Salt Export Pump, ABCB11, ATP-bindende Kassette Unterfamilie B Mitglied 11
Gen: ABCB11
ATP/AMP-Ratio: >10 (garantiert)
Gewebsexpression: Kanalikuläre Plasmamembran der Hepatozyten
Erkrankungen: Erbliche und medikamenteninduzierte Cholestase (DILI)
Bekannte Substrate: Taurocholat, Pravastatin, Taurolithocholyl-3-Sulfat, konjugierte monovalente Gallensalze
In stock: Human, Katze, Hund
Kit-Inhalt (100 Reaktionen)
- Vesikel-Vial (100 Reaktionen), BSEP überexprimierende HEK293-abgeleitete Vesikel
- AMP-ATP-Lösung (100 mM), Cell4Pharma
- Assay-Puffer, Cell4Pharma
Anwendungen
- allensalztransport-Inhibitionsstudien (Cholestase-Risikoabschätzung)
- Drug-Induced Liver Injury (DILI) Screening
- Drug-Drug-Interaction-(DDI)-Studien gemäß FDA/EMA-Leitlinien
- Substratidentifikation für hepatische Efflux-Transporter
- High-Throughput-Screening (Radiolabel-, Fluoreszenz-, LC-MS-Detektion)
Regulatorische Konformität
Die Hemmung von BSEP ist ein etablierter Mechanismus der medikamenteninduzierten cholestatischen Leberschädigung. Die Bewertung der BSEP-Hemmung wird in den FDA (2017)- und EMA (2013)-DDI-Leitlinien als Teil des Transporter-Charakterisierungspakets für neue Molekülentitäten (NMEs) in der klinischen Entwicklung empfohlen.
Technische Spezifikationen
Wirtszelle: HEK293 (humane embryonale Nierenzelle)
Vesikeltyp: Inside-out-Membranvesikel
Format: 100 Reaktionen pro Kit
Detektion: Radiolabel / Fluoreszenz / LC-MS kompatibel
Lagerung: –80 °C
Verwandte Produkte
- Human Control Vesicle Kit (C4PVK009) – empfohlen als Negativkontrolle in BCRP-Transportassays
- Human MRP2 Vesicle Kit (C4PVK002) – for parallel hepatic efflux assessment
- Human BCRP Vesicle Kit (C4PVK006) – for complete efflux transporter panel
- ciPTEC-OAT1 Assay-Ready Cells – für zellbasierte Nephrotoxizitäts- und Transporterstudien
- Human Serum AB Male OTC (SeamlessBio) – zur Supplementierung von ciPTEC-Kulturmedien
Alle Produkte auf Anfrage.
Kontakt: [email protected] | Telefon: +49 851 37932226
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4.4 ★★★★★
Based on 7 reviews
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Product Reviews
★★★★★ 4
An Amazing Debut! Dual Timeline, Second Chance Romance, and very well written!!
Format: Paperback
4.5/5 stars ⭐️ 304 pages 📚
🎶 Right Where You Left Me - Taylor Swift
“They knew. Some people are lucky like that. They meet their best friend, the love of their life, and are wise enough to never let go.”
In case you needed anyone else on Booksta to tell you to read this book, PLEASE go read this book!! I had very high expectations after seeing dozens of raving reviews and the story met every one! We follow Sam and Percy in a dual timeline (from Percy’s POV) through flashbacks of their teenage summers and their reunion over a decade later. I adored the flashback chapters. Watching Sam and Percy grow from awkward 13 year olds into early adulthood was nostalgic. It’ll take you back to your own childhood and the excitement and nerves of experiencing your first love. Though I did suspect what the cause of their breakup would be, it didn’t take away from any of the emotions or heartbreak I felt during those scenes! Carley has a very captivating writing style and you’ll fall in love with aspects of every character.
I only felt like the last 15% was a bit rushed! The buildup was fantastic, and the betrayal was anticipated, but I was hoping for a little bit more out of the conflict, how it affected other relationships, and moving on. An extended epilogue would’ve been perfect for this book! For a debut novel, Carley did outstanding and I’m excited to see what she comes up with next! Read this if you enjoy:
⏰ dual timeline
✨ second chance romance
💖 best friends to strangers to lovers
☀️ summer vibes!
🌊 small town romance
👩👦👦 emphasis on family
If you enjoyed Love and Other Words, you will LOVE this! Very similar style and vibes.
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Reviewed in the United States on August 1, 2022
★★★★★ 5
Phenomenal
Format: Kindle
Truly a wonderful read. I picked it up after absolutely falling in love with her latsest novel 'Our Perfeect Storm' (another good read), convinced that Carley Fortune is going to be the next big thing in romance. After finishing this book, im a believer. Its filled with tension and heartbreak, and laughter. It made me sob, it made me giggle, it even made me a little giddy. I could not put it down, and I'm sure you wont either, if you're already here.
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Reviewed in the United States on June 1, 2026
★★★★★ 3
Not my favorite by her
Format: Paperback
I have to say that Carley Fortune can write a really beautiful love story. I enjoyed this one but not nearly as much as This Summer Will be Different.
Sam is absolutely precious and his brother Charlie is trouble with a capital T but in the funniest and sweetest way (for the most part). And Percy's journey from 13 to 30 is a nice development throughout.
I enjoy the multiple timelines and to see Percy and Sam's love for each other grow from meeting the summer they turn 13. This story is both heartwarming and heartbreaking at the same time.
SPOILER: DON'T READ FURTHER IF YOU DON'T WANT ANYTHING SPOILED!!!
I was ready to give this book at least a 3.5 ⭐ until the cheating with the brother. Of course it was a one time regrettable mistake, but I am auto out on a cheating trope. And making it with his brother just sets the relationship up for failure no matter how many promises of forgiveness. But that's just my opinion. So be warned.
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Reviewed in the United States on January 30, 2026
★★★★★ 5
Such a good read
Format: Paperback
This is the absolute cutest book. I’ve read in a very long time! If you were someone growing up in the early mid 2000s, you are going to love this book, it hits all the nostalgic spots, and it makes you really think about your childhood again… I give it a 10 out of 10 highly recommend it super cute read. I read it in like five days between work and other things I had to get done.
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Reviewed in the United States on May 24, 2026
★★★★★ 5
Perfect for Homeschooling!! Let the stories come alive and captivate you!
Format: Hardcover
I’m a homeschooling mama and I’m grateful for men like Eric Metaxas who are personally invested in the wellbeing of our nation. Thank you, Eric, for sharing history with truth and the fear of God.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on June 2, 2026
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