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Description
AKAP4 Recombinant Rabbit mAb,PBS Only (SDT-4196)Product Specification Host Rabbit Antigen AKAP4 Synonyms A kinase anchor protein 4; AKAP 4; A kinase anchor protein 82 kDa (AKAP 82; hAKAP82); Major sperm fibrous sheath protein (HI); Protein kinase A anchoring protein 4 (PRKA4); AKAP82 Location Cell projection Accession Q5JQC9 Clone Number SDT 4196 Antibody Type Recombinant mAb Isotype IgG Application IHC P, IF Reactivity Hu Purification Protein A Concentration 1 mg ml Conjugation Unconjugated
Product Specification
| Host | Rabbit |
| Antigen | AKAP4 |
| Synonyms | A-kinase anchor protein 4; AKAP-4; A-kinase anchor protein 82 kDa (AKAP 82; hAKAP82); Major sperm fibrous sheath protein (HI); Protein kinase A-anchoring protein 4 (PRKA4); AKAP82 |
| Location | Cell projection |
| Accession | Q5JQC9 |
| Clone Number | SDT-4196 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | IHC-P, IF |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS |
| Stability & Storage | 12 months from date of receipt / reconstitution, 4 °C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:2000 | Hu |
| IF | 1:500 | Hu |
Background
AKAP4, the most abundant protein of the sperm fibrous sheath, is a testis-enriched scaffolding protein that simultaneously binds PKA via dual-specificity anchoring sites and PKC through polybasic motifs, thereby acting as a cAMP/PKA ↔ PKC/ERK1/2 switch that is phosphorylated on Ser/Tyr during capacitation to direct the kinase cascade to the flagellar principal piece, mid-piece and post-acrosomal region, enabling progressive motility and male fertility while also moonlighting in multiple cancers where its cytoplasmic/membrane accumulation drives proliferation, EMT and metastasis through the Shh and Wnt/β-catenin pathways.
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