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Description
ATR Recombinant Rabbit mAb (S-3506-59)Product Specification Host Rabbit Antigen ATR Synonyms Serine threonine protein kinase ATR; Ataxia telangiectasia and Rad3 related protein; FRAP related protein 1; FRP1 Immunogen Synthetic Peptide Location Nucleus Accession Q13535 Clone Number S 3506 59 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu Positive Sample Caco 2, A431, HeLa, HT 29 Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical
Product Specification
| Host | Rabbit |
| Antigen | ATR |
| Synonyms | Serine/threonine-protein kinase ATR; Ataxia telangiectasia and Rad3-related protein; FRAP-related protein 1; FRP1 |
| Immunogen | Synthetic Peptide |
| Location | Nucleus |
| Accession | Q13535 |
| Clone Number | S-3506-59 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu |
| Positive Sample | Caco-2, A431, HeLa, HT-29 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
Background
ATR (Ataxia Telangiectasia and Rad3-related) protein is a serine/threonine kinase that serves as a master regulator of the DNA damage response (DDR), particularly in response to replication stress and DNA double-strand breaks; it is recruited to sites of DNA damage through its interaction with RPA-coated single-stranded DNA (ssDNA) and the Rad9-Rad1-Hus1 (9-1-1) clamp complex, whereupon it phosphorylates key downstream substrates including the checkpoint kinase Chk1, p53, BRCA1, and RAD51 to initiate cell cycle arrest, facilitate DNA repair, and prevent replication fork collapse, thereby maintaining genomic integrity and preventing tumorigenesis, with its dysregulation being implicated in various cancers and its inhibition emerging as a promising therapeutic strategy for cancer treatment.
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